Physical causes include acute trauma to the body, repetitive motions affecting the spine, bad postural habits, improper workstation habits and design, and weak or imbalanced spinal musculature.

Chemical causes include poor dietary and nutritional practices, drug and alcohol use and abuse, and the ingestion of chemical toxins in the foods we eat, air we breathe, and water we drink. Chemicals, which are harmful to the body, decrease the body's ability to function optimally and reduce the ability to successfully adapt to and withstand internal and external stresses - making us more susceptible to spinal subluxations and the consequences of these subluxations.

Emotional causes refer to stress. Excessive stress or inadequate stress management skills can deplete the body of the ability to sustain normal functions. The impact of emotional stress on physical health is well documented in the medical research and can have devastating effects on the immune system, making the body susceptible to injury and disease.